Iodinin as an anti-hypertensive agent

ABSTRACT

A method of reducing blood pressure in hypertensive patients by administering a therapeutically effective amount of iodinin to said patients.

United States Patent [191 Jones et al.

IODININ AS AN ANTl-HYPERTENSIVE AGENT Inventors: Peter Hadley Jones, Lake Forest;

Pitambar Somani, Village of Libertyville, both of III.

Abbott Laboratories, North Chicago, Ill.

Filed: Mar. 20, 1972 Appl. No.: 236,179

Assignee:

US. Cl. 424/250 Int. Cl. A6lk 27/00 Field of Search 424/250 Primary Examiner-Jerome D. Goldberg AttorneyRobert L. Niblack 57 I ABSTRACT A method of reducing blood pressure in hypertensive patients by administering a therapeutically effective amount of iodinin to said patients.

-1 Claim, No Drawings IODININ AS AN ANTI-HYPERTENSIVE AGENT DETAILED DESCRIPTION OF THE INVENTION This invention relates to a method of reducing blood pressure in hypertensive patients using iodinin as the anti-hypertensive agent.

lodinin is represented by the formula The compound can be prepared according to the method described by U.S. Pat. No. 3,432,505.

lodinin has previously been reported to be an antibacterial agent (see U.S. Pat. No. 3,432,505). We have unexpectedly found that iodinin is an effective antihypertensive agent.

The anti-hypertensive activity of iodinin was first established in the spontaneously hypertensive rat procedure, Tabei et al. Clin. Pharmac. and Therap., ll (2): 269-274, (1970).

lodinin is effective as an anti-hypertensive agent at dosages of from approximately 0.1 to approximately 300 mg./kg. of body weight daily and is administered to hypertensive patients at such dosages, preferably by the oral route in divided dosages i.e., 3 to 4 times daily. It may also be co-administered with, for example, diuretics or tranquilizers.

The oral LD of iodinin is greater than 1 gram/kg. Therefore, a good therapeutic index of safety is present.

While iodinin can be administered alone, that is, as a sole component of a filled capsule, it is preferred to formulate the compound in various dosage forms for oral or parenteral administration, such as tablets, syrups, sterile aqueous or non-aqueous suspensions and the like. The oral dosage forms are prepared by the methods well known in the art, as are the parenteral and generally include a pharmaceutically acceptable carrier or diluent.

We claim:

1. A method of lowering blood pressure in a hypertensive patient comprising administering a therapeutically effective amount of iodinin to said patient. 

